Reprinted from
THE CANADIAN MEDICAL ASSOCIATION JOURNAL
41, 263-265, 1939
ACTIVE IMMUNIZATION AGAINST WHOOPING-COUGH*
BY NELLES SILVERTHORNE, M.B.
Toronto
IN recent years a number of publications have appeared on the use of fresh strain pertussis vaccine in the immunization of children against whooping-cough. Madsen,1 Sauer,2 Macdonald and Macdonald, Park, Kendrick and Eldering,5 Daughtry-Denmark, Kramer," Howell, Singer- Brooks, Miller, 10 Silverthorne, Fraser and Brown,11 and Silverthorne and Fraser12 have reported results which suggest that children may be successfully immunized. On the other hand, Doull, Shibley and McClelland13 and Siegel14 in their studies show little if any difference between the incidence of whooping-cough in control and vaccinated children. The present communication may for convenience be divided into two parts: Part I.-A progress report on the use of fresh strain pertussis vaccine in active immunization against whooping-cough. Part II.-A preliminary report on the minimal protective dose of fresh strain pertussis vaccines in mice.
PART I.
Clinical material.-Over the course of six years an opportunity has been afforded to follow [end of text]
*From the Connaught Laboratories, University_of Toronto; and the Hospital for Sick Children and Department of Pediatrics, University of Toronto, under the direction of Alan Brown, M.D., F.R.C.P.(C.).
Read at the Annual Meeting of the Canadian Medical Association, Section of Pediatrics, Montreal, June 22, 1939. 1